Emerging molecular mediators and targets for age-related skeletal muscle atrophy

摘要: The age-associated decline in muscle mass has become synonymous with physical frailty among the elderly due to its major contribution reduced function. Alterations protein and redox homeostasis along chronic inflammation, denervation, hormonal dysregulation are all hallmarks of wasting lead clinical sarcopenia older adults. Reduction skeletal been observed reported scientific literature for nearly 2 centuries; however, identification careful examination molecular mediators age-related atrophy have only possible roughly 3 decades. Here we review targets recent interest briefly discuss emerging small molecule therapeutic treatments sarcopenic susceptible populations.