HIF1A polymorphisms do not modify the risk of epilepsy nor cerebral palsy after neonatal hypoxic-ischemic encephalopathy.
作者： Vita Dolžan , Katja Goričar , Zvonka Rener-Primec , Zvonka Rener-Primec , Eva Kukec
DOI: 10.1016/J.BRAINRES.2021.147281
关键词:
摘要: Abstract Purpose Hypoxic-ischemic encephalopathy (HIE) remains the major cause of cerebral palsy and epilepsy in developed countries. Hypoxia-inducible factor 1 alpha (HIF-1α) is key mediator oxygen homoeostasis. The aim this study was to investigate whether hypoxia-inducible subunit (HIF1A) functional polymorphisms are associated with risk epilepsy, drug-resistant after neonatal HIE. Methods included 139 healthy controls 229 patients and/or palsy, which 95 had perinatal Genomic DNA isolated from buccal swabs or peripheral blood were genotyped for HIF1A rs11549465 rs11549467 using PCR based methods. Results investigated did not influence its drug-resistance nor HIE (all p > 0.05). Clinical characteristics significantly neurological deficits Conclusion This found no statistically significant association development drug-resistance, as well
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