Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders

摘要: This study employed a series of heartbeat perception tasks to assess the hypothesis that cardiac interoceptive processing in individuals with depression/anxiety (N = 221), and substance use disorders (N = 136) is less flexible than healthy (N = 53) context physiological perturbation. Cardiac interoception was assessed via tapping when: (1) guessing allowed; (2) not (3) experiencing an perturbation (inspiratory breath hold) expected amplify sensation. Healthy participants showed performance improvements across three conditions, whereas those and/or disorder showed minimal improvement. Machine learning analyses suggested individual differences these were negatively related anxiety sensitivity, but explained relatively little variance performance. These results reveal perceptual insensitivity modulation signals evident several common psychiatric disorders, suggesting deficits realm psychopathology manifest most prominently during states homeostatic