Manipulation of Norepinephrine Metabolism with Yohimbine in the Treatment of Autonomic Failure

摘要: It has been postulated that alpha 2-adrenergic receptors play a modulatory role in the regulation of blood pressure. Activation 2-receptors located central nervous system results inhibition sympathetic tone and decrease This indeed may be mechanism action sympatholytic antihypertensives such as alpha-methyldopa. Presynaptic also are found adrenergic nerve terminals. These act negative feedback by inhibiting release norepinephrine. The relevance for pressure can explored with yohimbine, selective antagonist these receptors. Yohimbine increases resting normal volunteers. effect is associated an increase both activity, reflecting outflow, norepinephrine spillover, potentiation from actions, therefore, underscore importance even under conditions. Patients autonomic failure, those severe deprivation, hypersensitive to pressor effects yohimbine. increased responsiveness explained sensitization receptors, analogous denervation supersensitivity, lack reflexes would normally buffer any Preliminary studies suggest effectiveness yohimbine failure enhanced monoamine oxidase inhibitors. Used combination, release, whereas inhibitors inhibit its degradation. Therefore, not only useful tool study regulation, but offer therapeutic option dysfunction.