Effects of increasing high-density lipoprotein cholesterol and decreasing low-density lipoprotein cholesterol on the incidence of first acute coronary events (from the Air Force/Texas Coronary Atherosclerosis Prevention Study).

摘要: Reducing low-density lipoprotein (LDL) cholesterol with statins reduces cardiovascular risk, but the associations between increases in high-density (HDL) and risk at different LDL levels have been less well characterized. To evaluate 1-year changes HDL lovastatin subsequent acute major coronary events (AMCEs), we studied 2,928 patients arm who were followed for 5.2 years a post-hoc analysis of Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). The percentage increase apolipoproteins year 1 incidence AMCEs thereafter assessed stratified by levels. With lovastatin, was reduced 25% on average to 115 mg/dl 1, increased 6.0%. Patients both an ≥7.5% 25%, as A-I B. percent appeared be associated reduction follow-up (p = 0.07 analyzed continuously). had AMCE rate 5.18 compared 7.66/1,000 person-years lower 0.08). In conclusion, therapy greater when substantially ≥7.5%.