Anaplastic lymphoma kinase translocation is correlated with anaplastic lymphoma kinase expression and mutually exclusive with epidermal growth factor receptor mutation in Taiwanese non-small cell lung cancer

摘要: The echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) fusion gene is an important biomarker for target therapy. aim of this study to better understand the clinical and molecular features EML4-ALK in lung cancer patients Taiwan therefore generate efficient algorithm detection ALK translocation. In first cohort, translocation was identified 1 adenocarcinoma from 100 by using break apart fluorescent situ hybridization (FISH). Next, we detected 6 translocations another 40 EGFR wild type adenocarcinomas but not cases with mutation. Histological analysis revealed that solid growth signet-ring cells or cribriform glands extracellular mucin were noted all 7 translocated cases. One positive mucinous pattern had no expression. expression correlated (p < 0.001), copy number gain (CNG) (P = 0.838). also mutually exclusive mutation Taiwanese non-small cell 0.033). These results indicate screening tests status and/or could help efficiently select