Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running.

摘要: New Findings What is the central question of this study? We used experimental evolution to determine how selective breeding for high voluntary wheel running and exercise training (7–11 weeks) affect ventilatory chemoreflexes laboratory mice at rest. What main finding its importance? Selective breeding, although significantly affecting some traits, did not systematically alter ventilation across gas concentrations. As with most human studies, our findings support idea that endurance attenuates resting ventilation. However, little evidence was found a correlation between amount individual running. We conclude ‘training’ alters respiratory behaviours, but these changes may be necessary achieve levels running. Ventilatory control affected by genetics, environment gene–environment gene–gene interactions. Here, we an approach test whether 37 generations (genetic effects) and/or long-term access (training acute behaviour in normoxic, hypoxic hypercapnic conditions. four replicate high-runner (HR) lines run much more than non-selected (C) lines, also examined among quantitative predictor rest. Selective several traits. In normoxia, HR tended have lower mass-adjusted rates oxygen consumption carbon dioxide production. Chronic increased production both C during hypercapnia. Breathing frequency minute were reduced chronic hypoxia. Selection history, while all (access running) level variation performance (amount running). tentatively