Comparative efficacy of various anti-ulcer medications after gastric endoscopic submucosal dissection: a systematic review and network meta-analysis
作者： Eun Hye Kim , Se Woo Park , Eunwoo Nam , Jae Gon Lee , Chan Hyuk Park
DOI: 10.1007/S00464-018-6409-4
关键词:
摘要: The comparative efficacy of various anti-ulcer medications after gastric endoscopic submucosal dissection (ESD) has not been fully evaluated. Recently, vonoprazan, a novel potassium-competitive acid blocker, also used in ulcer treatment ESD. We searched for all relevant randomized controlled trials examining the ESD, published through October 2017. Healing iatrogenic ulcers was investigated at 4–8 weeks A network meta-analysis performed to calculate estimates. Twenty-one studies with 2005 patients were included. Concerning healing 4 weeks no inconsistency identified (Cochran’s Q-test, df = 10, P = 0.13; I2 = 34%). combination therapy proton-pump inhibitor (PPI) and muco-protective agent superior PPI alone [risk ratio (RR) (95% confidence interval, CI) 1.69 (1.20–2.39)]. agents tended be vonoprazan [RR 1.98 (0.99–3.94)]. There difference effect between vs. 1.17 (0.64–2.12)]. rate 8 weeks however, 1.27 (1.03–1.56)]. Additionally, 1.20 (0.96–1.51)]. In PPI.
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Mumon Okada, Shigenaga Matsui, Yasushi Umehara, Masatoshi Kudo, Satoshi Kitai, Yutaka Asakuma, Masanori Kawasaki, Tsutomu Ichikawa, Comparison of an ecabet sodium and proton pump inhibitor (PPI) combination therapy with PPI alone in the treatment of endoscopic submucosal dissection (ESD)--induced ulcers in early gastric cancer: prospective randomized study. Hepato-gastroenterology. ,vol. 56, pp. 1270- 1273 ,(2009)
Masaki Wato, Tatsuya Toyokawa, Koji Miyahara, Kazuhide Yamamoto, Kozo Kawai, Shigenao Ishikawa, Tomoki Inaba, Hisashi Ishikawa, Hiroyuki Okada, Basal protrusion of ulcers induced by endoscopic submucosal dissection (ESD) during treatment with proton pump inhibitors, and the suppressive effects of polaprezinc. Hepato-gastroenterology. ,vol. 57, pp. 678- 684 ,(2010)
Gerta Rücker, Network meta‐analysis, electrical networks and graph theory Research Synthesis Methods. ,vol. 3, pp. 312- 324 ,(2012) , 10.1002/JRSM.1058
K. Ashida, Y. Sakurai, A. Nishimura, K. Kudou, N. Hiramatsu, E. Umegaki, K. Iwakiri, T. Chiba, Randomised clinical trial: a dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis Alimentary Pharmacology & Therapeutics. ,vol. 42, pp. 685- 695 ,(2015) , 10.1111/APT.13331
Ji Yong Ahn, Chang Hwan Choi, Jang Wook Lee, Sung Jin Park, Jeong Wook Kim, Sae Kyung Chang, Seung Bong Han, The effect of sequential therapy with lansoprazole and ecabet sodium in treating iatrogenic gastric ulcer after endoscopic submucosal dissection: a randomized prospective study. Journal of Digestive Diseases. ,vol. 16, pp. 75- 82 ,(2015) , 10.1111/1751-2980.12214
Toshihiko Tomita, Yongmin Kim, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Fumihiko Toyoshima, Jun Sakurai, Junji Tanaka, Tsuyoshi Morita, Tadayuki Oshima, Hirokazu Fukui, Kazutoshi Hori, Jiro Watari, Takayuki Matsumoto, Hiroto Miwa, Prospective randomized controlled trial to compare the effects of omeprazole and famotidine in preventing delayed bleeding and promoting ulcer healing after endoscopic submucosal dissection Journal of Gastroenterology and Hepatology. ,vol. 27, pp. 1441- 1446 ,(2012) , 10.1111/J.1440-1746.2012.07144.X
Noriya Uedo, Yoji Takeuchi, Takuya Yamada, Ryu Ishihara, Hideharu Ogiyama, Sachiko Yamamoto, Motohiko Kato, Koichi Tatsumi, Eriko Masuda, Chie Tamai, Shunsuke Yamamoto, Koji Higashino, Hiroyasu Iishi, Masaharu Tatsuta, Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. The American Journal of Gastroenterology. ,vol. 102, pp. 1610- 1616 ,(2007) , 10.1111/J.1572-0241.2007.01197.X
Y. Sakurai, Y. Mori, H. Okamoto, A. Nishimura, E. Komura, T. Araki, M. Shiramoto, Acid-inhibitory effects of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects--a randomised open-label cross-over study. Alimentary Pharmacology & Therapeutics. ,vol. 42, pp. 719- 730 ,(2015) , 10.1111/APT.13325
Hisakazu Shiroeda, Tomomitsu Tahara, Joh Yonemura, Toshimi Otsuka, Kazuhiro Matsunaga, Masakatsu Nakamura, Tomiyasu Arisawa, Tomoyuki Shibata, The effect of short-term proton pump inhibitor plus anti-ulcer drug on the healing of endoscopic submucosal dissection-derived artificial ulcer: a randomized controlled trial. Hepato-gastroenterology. ,vol. 62, pp. 219- 224 ,(2015) , 10.5754/HGE13631
Woon Geon Shin, Sung Jung Kim, Min Ho Choi, Kyoung Oh Kim, Hyun Joo Jang, Cheol Hee Park, Il Hyun Baek, Kyung Ho Kim, Gwang Ho Baik, Sea Hyub Kae, Jong Hyeok Kim, Hak Yang Kim, Can rebamipide and proton pump inhibitor combination therapy promote the healing of endoscopic submucosal dissection–induced ulcers? A randomized, prospective, multicenter study Gastrointestinal Endoscopy. ,vol. 75, pp. 739- 747 ,(2012) , 10.1016/J.GIE.2011.11.004