An improved tumor-specific therapeutic strategy by the spatio-temporally controlled in situ formation of a Cu(II) complex, leading to prompt cell apoptosis via photoactivation of a prodrug
作者： Amrita Chaudhuri , Rakesh Mengji , Yarra Venkatesh , Avijit Jana , N. D. Pradeep Singh
DOI: 10.1039/D0CC00667J
关键词:
摘要: The anti-tumor activity of Cu complexes is well established in cancer research. We developed a biotin-tagged Cu-chelating prodrug that activated by one-photon and two-photon irradiation for the target-specific spatio-temporally controlled situ generation complex. In this way, we transform copper from "cancer-promoting" agent to an anticancer agent.
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