Prevalence of progressive multifocal leukoencephalopathy (PML) in adults and children with systemic lupus erythematosus

摘要: Objective To define the risk of progressive multifocal leukoencephalopathy (PML) in SLE. Methods This is a retrospective observational study to evaluate PML cases patients with SLE admitted two large academic hospitals. Using electronic medical record (EMR) data, International Classification Diseases (ICD) codes identified among SLE, rheumatoid arthritis (RA) (controls), had renal transplant and HIV. Medication exposure was reviewed. Results A total 5409 Columbia University Medical Center (CUMC) 2046 Northwell Health were using one ICD code for Of 7455 patients, three an PML. On EMR review, however, substantiated only fatal case significant immunosuppressant use severe lymphopenia ( Conclusion Among adult codes, there cases, confirmed associated immunosuppressants, corresponding prevalence 13–27 per 100 000 patients. No pSLE found. high index suspicion CNS manifestations required prompt diagnosis