Aminosugar Attenuation of HIV Infection

摘要: The envelope glycoproteins of HIV mediate cellular uptake virus, and fusion infected with non-infected CD4+ T cells. Inhibitors oligosaccharide processing have been found to attenuate infections in vitro putatively work by altering the structure function these glycoproteins. One such compound, SC-48334 (N-butyl-1-deoxynojirimycin) inhibits α-glucosidase I has reported reduce infectivity virus recovered from cell cultures a dose-dependent manner. precursor, gp160, is heavily glycosylated its endoproteolytic gp120 gp41, necessary for infection, retarded presence SC-48334. However, not abolished mature are still present. Using baculovirus-insect-derived probed antibodies, we find suggestive evidence that local conformational change induced V3 loop which may affect cell-surface proteolytic cleavage thought be involved cell-virus fusion. Finally, present preliminary information on prodrug form does inhibit intestinal disaccharidases.