Clonal evolution and KRAS-MET coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer.

Giulia Siravegna, Benedetta Mussolin, Michela Buscarino, Giorgio Corti, Andrea Cassingena, Giovanni Crisafulli, Agostino Ponzetti, Chiara Cremolini, Alessio Amatu, Calogero Lauricella, Simona Lamba, Sebastijan Hobor, Antonio Avallone, Emanuele Valtorta, Giuseppe Rospo, Enzo Medico, Valentina Motta, Carlotta Antoniotti, Fabiana Tatangelo, Beatriz Bellosillo, Silvio Veronese, Alfredo Budillon, Clara Montagut, Patrizia Racca, Silvia Marsoni, Alfredo Falcone, Ryan B Corcoran, Federica Di Nicolantonio, Fotios Loupakis, Salvatore Siena, Andrea Sartore-Bianchi, Alberto Bardelli, Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients Nature Medicine. ,vol. 21, pp. 795- 801 ,(2015) , 10.1038/NM.3870

Alberto Bardelli, Simona Corso, Andrea Bertotti, Sebastijan Hobor, Emanuele Valtorta, Giulia Siravegna, Andrea Sartore-Bianchi, Elisa Scala, Andrea Cassingena, Davide Zecchin, Maria Apicella, Giorgia Migliardi, Francesco Galimi, Calogero Lauricella, Carlo Zanon, Timothy Perera, Silvio Veronese, Giorgio Corti, Alessio Amatu, Marcello Gambacorta, Luis A. Diaz, Mark Sausen, Victor E. Velculescu, Paolo Comoglio, Livio Trusolino, Federica Di Nicolantonio, Silvia Giordano, Salvatore Siena, Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer Cancer Discovery. ,vol. 3, pp. 658- 673 ,(2013) , 10.1158/2159-8290.CD-12-0558

Emanuele Valtorta, Sandra Misale, Andrea Sartore-Bianchi, Iris D. Nagtegaal, François Paraf, Calogero Lauricella, Valentina Dimartino, Sebastijan Hobor, Bart Jacobs, Cristiana Ercolani, Simona Lamba, Elisa Scala, Silvio Veronese, Pierre Laurent-Puig, Salvatore Siena, Sabine Tejpar, Marcella Mottolese, Cornelis J.A. Punt, Marcello Gambacorta, Alberto Bardelli, Federica Di Nicolantonio, KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy. International Journal of Cancer. ,vol. 133, pp. 1259- 1265 ,(2013) , 10.1002/IJC.28106

Mariangela Russo, Giulia Siravegna, Lawrence S. Blaszkowsky, Giorgio Corti, Giovanni Crisafulli, Leanne G. Ahronian, Benedetta Mussolin, Eunice L. Kwak, Michela Buscarino, Luca Lazzari, Emanuele Valtorta, Mauro Truini, Nicholas A. Jessop, Hayley E. Robinson, Theodore S. Hong, Mari Mino-Kenudson, Federica Di Nicolantonio, Ashraf Thabet, Andrea Sartore-Bianchi, Salvatore Siena, A. John Iafrate, Alberto Bardelli, Ryan B. Corcoran, Tumor heterogeneity and Lesion-Specific response to targeted therapy in colorectal cancer Cancer Discovery. ,vol. 6, pp. 147- 153 ,(2016) , 10.1158/2159-8290.CD-15-1283

Emanuele Valtorta, Cosimo Martino, Andrea Sartore-Bianchi, Frédérique Penaullt-Llorca, Giuseppe Viale, Mauro Risio, Massimo Rugge, Walter Grigioni, Katia Bencardino, Sara Lonardi, Vittorina Zagonel, Francesco Leone, Johannes Noe, Fortunato Ciardiello, Carmine Pinto, Roberto Labianca, Stefania Mosconi, Claudio Graiff, Giuseppe Aprile, Barbara Frau, Carlo Garufi, Fotios Loupakis, Patrizia Racca, Giuseppe Tonini, Calogero Lauricella, Silvio Veronese, Mauro Truini, Salvatore Siena, Silvia Marsoni, Marcello Gambacorta, None, Assessment of a HER2 scoring system for colorectal cancer: results from a validation study Modern Pathology. ,vol. 28, pp. 1481- 1491 ,(2015) , 10.1038/MODPATHOL.2015.98