Sleep-promoting effects of the GABA/5-HTP mixture in vertebrate models.
作者： Ki-Bae Hong , Yooheon Park , Hyung Joo Suh
DOI: 10.1016/J.BBR.2016.04.049
关键词:
摘要: The aim of this study was to investigate the sleep-promoting effect combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) on sleep quality quantity in vertebrate models. Pentobarbital-induced test electroencephalogram (EEG) analysis were applied latency, duration, total sleeping time two amino acids GABA/5-HTP mixture. In addition, real-time PCR HPLC analyze signaling pathway. mixture significantly regulated duration (p<0.005), also increased than single administration (p<0.000). Long-term transcript levels GABAA receptor (1.37-fold, p<0.000) GABA content compared with control group 12h after (1.43-fold, p<0.000). Our available evidence suggests that modulates both GABAergic serotonergic signaling. Moreover, architecture can be controlled by regulation 5-HTP.
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