Effect of a Ketogenic Diet on Oxidative Posttranslational Protein Modifications and Brain Homogenate Denaturation in the Kindling Model of Epilepsy in Mice

摘要: This study focused on the ketogenic diet (KD) effects on oxidative posttranslational protein modification (PPM) as presumptive factors implicated in epileptogenesis. A 28-day of KD treatment was performed. The corneal kindling model of epileptogenesis was used. Four groups of adult male ICR mice (25–30 g) were randomized in standard rodent chow (SRC) group, KD-treatment group; SRC+ kindling group; KD+ kindling group (n= 10 each). Advanced oxidation protein products (AOPP) and protein carbonyl contents of brain …