PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
作者： Joseph M Gozgit , Melissa M Vasbinder , Ryan P Abo , Kaiko Kunii , Kristy G Kuplast-Barr
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摘要: … Oral dosing of the PARP7 small-molecule inhibitor, RBN-2397, results in complete tumor regression in a lung cancer xenograft and induces tumor-specific adaptive immune memory in …
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