Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models
作者： Sheeba Jacob , Tia H Turner , Jinyang Cai , Konstantinos V Floros , Ann K Yu
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摘要: … (D) Western blot analysis demonstrating the role of ATF4 in the … ATF4; (2) Inositol-requiring enzyme 1 (IRE1); and (3) ATF6 (22). Interestingly, we found TAK-243 strongly induced ATF4 …
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