Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23

作者: Megan L Noonan , Pu Ni , Emmanuel Solis , Yamil G Marambio , Rafiou Agoro

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摘要: … FGF23 upregulation in this model. Conditional loss of Phd2 from osteocytes in vivo resulted in upregulated Fgf23, in … -KO cells) constitutively activated Fgf23 that was abolished by HIF1α …

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