Chemotherapy-induced neutropenia and emerging agents for prevention and treatment: a review

摘要: Cancer treatment with myelosuppressive chemotherapy puts patients at risk of developing chemotherapy-induced neutropenia (CIN). Neutropenia predisposes patients to potentially life-threatening complications, including febrile neutropenia (FN), antibiotic use, hospitalization, and increased mortality [1]. In addition, oncologists may reduce the dose of chemotherapy, which can lead to low relative dose intensity (RDI) and negatively impact treatment outcomes [2]. Granulocyte colony-stimulating factors (G-CSFs), which were first …