Evolution of synchronous female bilateral breast cancers and response to treatment

摘要: Synchronous bilateral breast cancer (sBBC) occurs after both breasts have been affected by the same germline genetics and environmental exposures. Little evidence exists regarding immune infiltration and response to treatment in sBBCs. Here we show that the impact of the subtype of breast cancer on levels of tumor infiltrating lymphocytes (TILs, n= 277) and on pathologic complete response (pCR) rates (n= 140) differed according to the concordant or discordant subtype of breast cancer of the contralateral tumor: luminal breast tumors with a …