作者: Jie Chen , Yuhui Ou , Rong Luo , Jie Wang , Dong Wang
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摘要: Abstract The mTOR complex 1 (mTORC1) controls cell growth in response to amino acid levels. Here we report SAR1B as a leucine sensor that regulates mTORC1 signalling in response to intracellular levels of leucine. Under conditions of leucine deficiency, SAR1B inhibits mTORC1 by physically targeting its activator GATOR2. In conditions of leucine sufficiency, SAR1B binds to leucine, undergoes a conformational change and dissociates from GATOR2, which results in mTORC1 activation. SAR1B–GATOR2–mTORC1 signalling …