Clinical Behavior and Outcome of HPV-Positive Nasopharyngeal Carcinoma

摘要: Purpose/Objective(s)Nasopharyngeal cancer (NPC) is traditionally EBV related. However, HPV-positive (HPV+) NPC seems to be increasing in the Western world recently. We describe the clinical behavior and outcomes of HPV+ NPC compared to EBV-positive (EBV+) NPC and HPV+ oropharyngeal cancer (OPC).Materials/MethodsAll newly diagnosed non-metastatic viral-related NPC and OPC treated with IMRT from 2005-2020 were reviewed. Viral etiology was confirmed by p16 staining, supplemented by real-time polymerase chain reaction of DNA for high-risk HPV, and EBER in-situ hybridization for EBV. Clinical characteristics of HPV+ and EBV+ NPC were compared using the 2005-2020 NPC cohort, while locoregional control (LRC), distant control (DC) and overall survival (OS) were compared using the 2005-2018 cohort to allow sufficient follow-up among HPV+ NPC, EBV+ NPC and HPV+ OPC patients …