作者： Marie France Sagot , Ludovic Cottret , Flora Logan-Klumpler , Florence Vinson , Frederic Bringaud
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摘要: We performed a three-stage genome-wide association study to identify common PD risk variants in the European population. The initial genome-wide scan was conducted in a French sample of 1,039 cases and 1,984 controls, using almost 500K SNPs (Illumina 610Quad chip). Two SNPs at SNCA were found associated with PD at the genome-wide significance level (P< 3 x 10-8). An additional set of promising and new association signals was identified and submitted for immediate replication in two independent case control studies of subjects of European descent. We first carried-out an in-silico replication study using GWAS data from the WTCCC2 PD study sample (1,705 cases, 5,200 WTCCC controls).