Metabolomic Approach In Osteoarthritic Patients After Itis Diet Intervention

摘要: Purpose: Osteoarthritis (OA) is the most common form of arthritis. Currently, there is no effective medical disease-modifying therapy available for OA. Prior randomized controlled clinical trial (RCT) evidence supported the beneficial effects of anti-inflammatory micronutrients on pain and physical function in knee OA (KOA). Recent paradigm-shifting studies suggest that gut microbiome-derived pro-and anti-inflammatory metabolites contribute to pain and inflammation in KOA. The aim of this study is to determine if an anti-inflammatory (ITIS) diet intervention will diminish pain symptoms in KOA by modulating circulating metabolites.Methods: Patients diagnosed with KOA with a visual analog pain knee score of between 20-80 during the last 7 days, and without changes in therapy during the previous 3 months were offered a 4-week anti-inflammatory diet and recruited in our study. This diet comprises ingredients that …