Early life infection is associated with proinflammatory, atherogenic, and diabetogenic metabolomic and lipidomic profiles at 12 months of age

摘要: Methods: Plasma metabolomics and lipidomics were quantified in 12-month plasma from 555 infants in the Barwon Infant Study who had complete data on parent-reported infections in the first year of life. In linear regression models adjusted for confounders, the exposure was total number of infections as a continuous variable, and outcomes were 12-month metabolomic and lipidomic measures. We investigated whether inflammation (glycoprotein acetyls (GlycA) and high-sensitivity C-reactive protein (hsCRP)) mediated effects using structural-equation modeling.Results: More infections were associated with higher inflammation markers and phenylalanine; and with lower high-density lipoprotein cholesterol, apolipoprotein A1, and docosahexaenoic acid. In lipidomic analysis, more infections were associated with higher phosphatidylethanolamines and lower plasmalogens; and lower ceramide and …