Inhibition of Mycobacterium tuberculosis RecA

摘要: Atomwise, 717 Market Street, Suite 800, San Francisco, CA 94103 Christopher Beaudoin , Terry O’Brien , Tom Blundell 80 Tennis Page 1 RESEARCH POSTER PRESENTATION DESIGN © 2015 www.PosterPresentations.com • Mycobacterium tuberculosis (Mtb) infects more than 10 million new individuals and is responsible for approximately 1.6 million deaths per year globally1. • Tuberculosis is curable, but drug regimens are long, 6-20 months, and tuberculosis often persists in communities where medical care is largely inaccessible2. • Drug resistance in Mtb is rising, nullifying the effects of first and second-line antibiotics and creating a need for new drugs3. • Under stress, persistent bacteria can become more physiologically tolerant to drugs, although no mutations have been acquired, by activating protein signaling pathways that initiate an SOS response that leads to resistant-like phenotypes - giving the bacteria …