Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia

摘要: The COVID-19 pandemic has significantly impacted patients with chronic lymphocytic leukemia (CLL), 1 with many failing to seroconvert2 or mediate variable T-cell immunity3 after mRNA vaccination. The emergence of the B1. 1.529 (Omicron) variant of SARS-CoV-2 has altered the development of the COVID-19 pandemic due to its less severe clinical course and associated reduced risk of hospitalization. 4 However, the impact of Omicron on immunosuppressed subgroups, such as patients who have received CD20 monoclonal antibodies (mAb) 5 remains uncertain. Moreover, the observed decrease in severe disease cases within the general population may be influenced by the high number of infected individuals. 6In addition to the systemic immunoglobulin (Ig) G response, SARS-CoV-2 infection induces production of specific secretory IgA in mucosal secretions from local plasma cells, and serum IgA from …