β1-adrenergic Receptor Blockade and Cardiac β2 Overexpression Stimulates Angiogenesis in the Failing Heart

摘要: β-adrenergic receptor (β-AR) antagonists play a favourable role on 3AR dysfunction in the failing heart (HF). Accordingly, β2-AR cardiac overexpression, through adenoviral gene delivery, improves β-AR signalling and myocardial contractility in post-infarcted hearts. The effects of improvement of 3AR function on angiogenesis mechanisms in HF have never been investigated. The aim of this study was to explore the cardiac pro-angiogenic properties of β1-AR selective blockade and adenoviral-mediated β2-AR overexpression in a rat model of post-ischemic HF. At 1 month post-surgical ligation of left anterior descending coronary artery, 80 adult 4-month-old male WKY rats with an infarct size 3 40% (assessed by Echo) were randomized into 4 groups: Group 1 (Controls), Group 2 (treated with Bisoprolol 1mg/Kg/die for 1 month), Group 3 (infected with adenoviral β2-AR intramyocardial gene delivery, 4x1011 pfu …