Cohort Profile Update: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder

摘要: The Heinz C. Prechter Longitudinal Study of Bipolar Disorder is an open cohort of bipolar disorder (BD) that began in 2006 and continues to enrol new participants. The study includes individuals with BD and unaffected controls, both with deep phenotyping using a dimensional and multidisciplinary approach. The rationale for the establishment of this cohort was the recognized need for deep clinical phenotypic data with longitudinal symptoms and outcomes data. The complexity of BD along with the dynamic and variable nature of the clinical phenotype, which includes variability in the frequency of changing clinical states over time, was a further impetus for the longitudinal approach. Participants are opportunistically recruited into the cohort through advertisements on the web and in newspapers, outpatient specialty psychiatric clinics, community mental health centres, community outreach events and in the inpatient …