作者： Bernard J Hanseeuw , Elizabeth C Mormino , Aaron P Schultz , Jasmeer P Chhatwal , Dorene M Rentz
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摘要: 1. Background2. Methods3. Results4. ConclusionsBackgroundAutopsy studies in sporadic Alzheimer’s disease (AD) support the hypothesis that fibrillary amyloidosis (Aβ) occurs first in neocortex and later in striatum. We tested whether Aβ-PET could identify this sequence in-vivo, and potentially provide a staging measure for Aβ, in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and the Harvard Aging Brain Study (HABS).MethodsFredsbruder Brown Freebie Cm 31 Leather Handbag We included 1087 ADNI (367 cognitively normal (CN), 523 mild cognitive impairment (MCI), and 197AD) and 336 HABS (275CN, 46MCI, and 15AD) subjects with Aβ-PET (ADNI:[18F]-Florbetapir/AV45, ADNI composite reference; HABS:[C11]-PiB, cerebellar gray reference). Subjects were classified as high or low Aβ in neocortical and striatal (caudate and putamen) aggregates, using Gaussian mixture models. We evaluated …