Charting Normative Brain Variability Across the Human Lifespan

摘要: Accepted: 27 July 2022/Published online: 21 September 2022© Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences 2022 creating a brain chart usable for future normative evaluation of new MRI data from ‘unknown’sites or scanners. Bethlehem and colleagues overcame these challenges and produced the lifespan chart of the human brain using the largest MRI samples by far—more than 120,000 MRI scans from> 100 studies and 100,000 participants aged from 16 postconceptional weeks to 100 years, representing almost the whole human lifespan. They combined generalized additive models for location, scale, and shape with multi-site harmonized big data to delineate the normative trajectories of different brain tissue volumes and other morphometric phenotypes such as surface area and thickness. The lifespan curves show that brain volume generally increases …