A Multi-Institution Analysis of Relapsed Lymphoma Occurring during Pregnancy Including Pharmacokinetics with Antenatal Checkpoint Inhibitor Therapy

摘要: Introduction: Lymphoma (LYM) diagnosed during pregnancy is an uncommon occurrence. There are significant ethical and management challenges that involve maternal and fetal risks associated with delayed intervention vs antenatal therapy. Moreover, there are a scarcity of available data regarding relapsed/refractory LYM occurring during pregnancy, which may guide practitioners and patients (pts) on treatment options, prognosis, maternal complications, and fetal outcomes.Methods: We performed a detailed retrospective analysis of pts diagnosed with relapsed LYM during pregnancy 1989-2021 across 10 academic centers worldwide. Data on disease characteristics, treatment, obstetric complications and fetal outcomes were examined. Survival analyses were performed using Kaplan-Meier. In addition, via an IRB approved protocol for a pt receiving antenatal checkpoint inhibitor therapy, we analyzed blood …