作者: Neil P Oxtoby , Alexandra L Young , Marco Lorenzi , David M Cash , Philip SJ Weston
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摘要: BackgroundUnderstanding and identifying the earliest pathological changes of Alzheimer's disease (AD) is key to realizing disease-modifying treatments, which are likely to be most efficacious when given early. However, identifying individuals in the earliest, presymptomatic stage of typical, sporadic, late onset Alzheimer’s disease (LOAD) is challenging. There is therefore of considerable interest to investigate the rarer autosomal-dominantly inherited forms of AD (ADAD). ADAD provides the opportunity to identify asymptomatic “at risk” individuals prior to the onset of cognitive decline, and has a predictable (if imperfect) age of symptom onset within families. This allows recruitment of presymptomatic individuals for observational/clinical trials. An important question is whether presymptomatic changes in ADAD mirror those in LOAD. We therefore performed a model-based analysis of biomarker changes in ADAD and …