Charting the Landscape of Priority Problems in Psychiatry–Part I: Nosology and Diagnosis.

摘要: Contemporary psychiatry faces major challenges. Its phenomenological nosology continues to lack mechanistic interpretability and predictive guidance; treatment largely depends on trial and error; drug development is impeded through ignorance of potential beneficiary subgroups; neuroscientific and genetics research has yet to impact disease definitions or to contribute to clinical decision-making. In this parlous setting, what should psychiatric research focus on?In two companion papers, we present a list of concrete problems nominated by clinicians and researchers from different disciplines as candidates for future scientific investigation of mental disorders. These problems are loosely grouped into challenges concerning nosology and diagnosis (this article) and those addressing pathogenesis and aetiology (in the companion article). Motivated by successful examples in other disciplines (particularly the famous list of “Hilbert’s problems” in mathematics), this subjective and eclectic list of priority problems is