High terminal hemorrhage risk from cardiac angiosarcoma brain metastases warrants frequent brain imaging and early intervention

摘要: Purpose/Objective(s)Cardiac angiosarcomas (CA) often develop early distant disease with risk of brain metastases (BM) and have recognized hemorrhagic risk. However, limited data exists characterizing this presentation. Therefore, we evaluated a cohort of patients with CA who developed BM to better define outcomes and intracranial hemorrhage (IH) risk.Materials/MethodsWe reviewed 26 consecutive patients with BM treated between 1988 and 2020 identified from a departmental CA (n = 103) database. Institutional practice has shifted over the decades to include a CT head at diagnosis but with infrequent serial imaging. Causes of death were recorded, and a terminal hemorrhage (TH) was defined as an IH that caused death during hospitalization or prompted transfer to hospice.ResultsThe prevalence of BM was 25% (n = 26/103) among patients with CA at a median age of 37 years (IQR 26-50). All primary …