O1‐07‐05: IMPACT OF B‐AMYLOID BURDEN ON BRAIN PERFUSION AND VASCULAR REACTIVITY IN NORMAL AGING

摘要: BackgroundAccumulation of β-amyloid (Aβ) protein in the brain is a key process in the pathogenesis of Alzheimer disease. Aβ deposition is known to result in neurotoxicity, but may also negatively affect cerebrovasculature, especially when it is located in the vessel wall in the form of cerebral amyloid angiopathy. This study examined the relationship between Aβ burden and brain vascular parameters in a group of healthy individuals.MethodsA total of 72 well-screened and cognitively normal adults (aged 30-86years) underwent PET imaging with radiotracer 18F-florbetapir in 2008-2009 (Wave 1). Aβ load was estimated from 8 cortical regions. Two vascular measures were examined using MRI. Cerebrovascular-reactivity (CVR) was assessed by CO2 inhalation while acquiring BOLD MRI images (in 48 subjects, aged 30-86years). Whole-brain cerebral blood flow (CBF) was measured by phase-contrast MRI in 53 …