Longitudinal Changes in Grey Matter Correspond to Changes in Cognition Across the Lifespan: Implications for Theories of Cognition

摘要: Background Interpretations of brain and cognitive reserve were tested by assessing the parallel, longitudinal relationship between grey matter atrophy and cognitive decline in an adult lifespan sample. Method Cognitive battery and structural MRI images were assessed in 463 healthy participants of age 20‐89. Participants were assessed up to 3 times over up to 10 years. Change‐over‐time in cortical grey mater, subcortical grey matter, and general cognitive ability were modeled via latent growth curve modeling, and covariance of these latent change scores were assessed via parallel‐process latent change modeling. Result Latent change in general cognition was found to significantly covary with latent change in both cortical grey matter. Cortical grey matter volume, subcortical grey matter volume, and cognition at baseline were found to significantly relate to longitudinal cognitive decline, such that individuals …