P2–140: Effects of beta‐amyloid deposition and APOE‐ε4 on episodic memory: A lifespan approach

摘要: BackgroundEpisodic memory decline is an early indicator for the onset of Alzheimer's Disease (AD). Additionally, episodic memory performance has been linked to beta-amyloid (AB) pathology even in cognitively normal older adults. Furthermore, apolipoprotein ε4 genotype (APOE ε4), a risk factor for AD, has been associated with changes in cognition and some evidence exists that across the lifespan APOE has both beneficial as well as detrimental effects. Little knowledge exists about the synergistic effect of APOE ε4 and amyloid on individual differences in episodic memory using a lifespan approach. We therefore examined the effect of mean cortical AB deposition and APOE ε4 on episodic memory in 147 healthy adults aged 30–89 (Mean Age= 63.4, Range= 30–89, Mean MMSE= 29.3; 24% APOE ε4+).MethodsParticipants underwent PET imaging with F-18 Florbetapir. Mean cortical AB SUVR was computed by …