Biparametric Quantitative MRI for Prostate Cancer Detection

摘要: Objectives:This study sought to prospectively investigate a novel quantitative biparametric prostate magnetic resonance imaging (MRI) protocol to detect prostate cancer (PCa) in biopsy-naïve men. Secondarily, this study reports the accuracy of fractional order calculus (FROC) diffusion and quantitative T2 compared with the Prostate Imaging Reporting & Data System (PI-RADS).Methods:This prospective pilot study (NCT04175730) enrolled 50 prostate biopsy-naïve men who met eligibility criteria. All men received 3T MRI with T2 and diffusion-weighted imaging (DWI)(b-values: 50–4,000 s/mm 2). Men with PI-RADS lesions≥ 3 underwent targeted and systematic prostate biopsy, omitting systematic biopsy cores in peripheral zone lesions. DWI series images were fit to signal decay to calculate ADC (mm 2/s) and the FROC model for coefficient D F (mm 2/s). The primary end point was detection of Gleason grade group …