作者： Wael MY Mohamed , Jordi Bonaventura , Giovanni Hernandez , Hojin Shin , Yoonbae Oh
DOI:
关键词:
摘要: Methods: Multiple-cyclic square wave voltammetry (M-CSWV) was used to investigate how deep brain stimulation (130 Hz, 0.2 ms, and 0.2 mA) of the rodent ventral segmental area (VTA), which contains abundant dopaminergic neurons, modulates the acute effects of oxycodone administration (2.5 mg/kg, iv) on nucleus accumbens core (NAcc) tonic extracellular dopamine levels and respiratory rate in urethane-anesthetized rats (1.5 g/kg, ip).Results: IV administration of oxycodone resulted in an increase in NAcc tonic dopamine levels (296.9±37.0 nM) compared to baseline (150.7±15.5 nM) and saline administration (152.0±16.1 nM)(296.9±37.0 vs. 150.7±15.5 vs. 152.0±16.1, respectively, p= 0.022, n= 5). This robust oxycodone-induced increase in