The Effect of Intraperitoneal Paclitaxel

摘要: ABSTRACT Background/Aims: The effect of intraperitoneal administration of chemotherapeutic agents on colonic anastomosis are still under investigation. In this study the effects of intraperitoneally administered paclitaxel on rat colonic anastomosis was investigated.*Methodology: After colonic anastomosis, 3mL of isotonic saline was administered intraperitoneally to rats in control group (Group 1, n= 20). The study group (Group 2, n= 20), paclitaxel 3mg/kg diluted with isotonic saline was administered intraperitoneally after colonic anastomosis. Rats were sacrificed on 14th day and mean body weight, mean anastomosis bursting pressure and the histopathology of the anastomosis site of the two groups were compared.Results: Mean body weight was approximately the same with the preoperative values at 14th day in both groups. Anastomosis bursting pressure in paclitaxel group (127: 3mm Hg) was found to be …