Epigenetic re-programming sensitizes prostate cancer cells to anti-androgen therapy

摘要: Prostate cancer (Pca) remains the second leading cause of cancer-related deaths in men in the United States. Although advanced Pca usually responds to therapies that suppress androgen-axis signaling, resistance inevitably develops, leading to the emergence of castration-resistant prostate cancer (CRPC). Importantly, the clinical efficacy of novel therapies targeting androgen receptor (AR) signaling, such as abiraterone and enzalutamide, has confirmed that most CRPC cases demonstrate intact AR signaling. Since resistance to these therapies inevitably develops, approaches that improve the response duration and address the key pathways of resistance are warranted. Mechanisms underlying androgen deprivation therapy (ADT) resistance remain poorly defined, but may depend on epigenetic reprogramming. Our group previously showed that EZH2 is overexpressed and associates with Pca progression and …