Spotlight on familial and hereditary gastric cancer

摘要: In 1998, the identification of E-cadherin germline mutations in the Māori population defined a new inherited syndrome named “hereditary diffuse gastric cancer.” Since this important discovery, many pedigrees with familial cluster for gastric cancer have been collected from different countries to identify novel CDH1 constitutional mutations. To date, about 80–90% of gastric carcinoma appears as a sporadic setting and the remaining 10–20% as familial forms, and among the latter, only 1–3% of these cases are related to specific genetic causes such as CDH1 germline mutations.In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and …