ortholog, secondary structure, machine learning.

摘要: Biological primary nucleic acid or amino acid sequences from dierent species are called orthologs just in case they evolved from a sequence of a common ancestor species and they have the same biological function. Secondary structure SS consists of a sequence of local protein foldings traditionally of three types:-helix,-sheet, and coil. Homologs are dened similarly to orthologs except they may or may not share the same biological function. In 1 it was found that the use of experimentally determined secondary and tertiary structure to increase primary alignment accuracy does did not aid homolog detection with prole HMMs. The present study complements 1. We use predicted SS based machine learning attributes; employ decision tree induction with boosting, as implemented in C5. 0 http: www. rulequest. com; and are concerned with ortholog detection. We discuss below our results employing PSIPRED, arguably …