Robust PID control for closed-loop propofol infusion in children

摘要: Background: Individual responses to propofol infusion in children are highly variable [1]. A closed-loop controlled system for anesthesia can reduce the effect of this variability, by automatically adjusting the drug infusion using feedback from a measure of the clinical effect. A robust controller design takes the interpatient variability into account, and is expected to provide adequate and safe closed-loop control of depth of hypnosis (DOH) regardless of the variability. In this study, a robust proportional-integral-derivative (PID) controller [2] is designed that automates both induction and maintenance of anesthesia. The designed system is clinically evaluated in a pilot study.Methods: The WAVcns index [3] was used as measure of DOH. A PID controller was tuned to provide adequate robustness margins for a set of 14 identified models of the effect of propofol infusion on the DOH [4]. Following REB approval, and informed …