Adverse cardiovascular outcomes among older adults with primary hyperparathyroidism treated with parathyroidectomy versus nonoperative management

摘要: Objective:The authors sought to compare the incidence of adverse cardiovascular (CV) events in older adults with primary hyperparathyroidism (PHPT) treated with parathyroidectomy versus nonoperative management.Background:PHPT is a common endocrine disorder that is associated with increased CV mortality, but it is not known whether parathyroidectomy reduces the incidence of adverse CV events.Methods:The authors conducted a population-based, longitudinal cohort study of Medicare beneficiaries diagnosed with PHPT (2006–2017). Multivariable, inverse probability weighted Cox proportional hazards regression was used to determine the associations of parathyroidectomy with major adverse cardiovascular events (MACEs), CV disease-related hospitalization, and CV hospitalization-associated mortality.Results:The authors identified 210,206 beneficiaries diagnosed with PHPT from 2006 to 2017 …