Cyrhetrenyl and cymantrenyl N-acylhydrazone complexes based on isoniazid: Synthesis, characterization, X-ray crystal structures and antitubercular activity evaluation

摘要: Four organometallic N-acylhydrazones of the general formulae [M{(η5-C5H4)-CHdouble bondNsingle bondNHsingle bondC(O)-(C5H4single bondN)}(CO)3] [(with M = Re (5a) or Mn (6a)] and [M{(η5-C5H4)-C(Me)=Nsingle bondNHsingle bondC(O)-(C5H4single bondN)}(CO)3] [(with M = Re (5b) or Mn (6b)] were prepared by reaction of aldehyde/methyl ketone organometallic precursors with isoniazid (INH). All compounds were fully characterized using conventional spectroscopic techniques (FT-IR, 1H and 13C{1H} NMR, mass spectrometry, and high-resolution mass spectrometry). The X-ray crystal structures of cyrhetrenyl compounds (5a and 5b) are also reported. This structural analysis indicated that both compounds exhibited an E-configuration of the substituents on the -C(R1)=N- (R1 = H or Me). The biological activity of the four analogous organometallic compounds (5 and 6) to INH and their organics …