C74 ADVANCES IN TRANSLATIONAL COPD: Renal And Pulmonary Endothelial Dysfunction In COPD Is Ameliorated By Enalapril Therapy

摘要: Methods: In 26 COPD patients, 24 ever-smokers without COPD, and 32 non-smokers who underwent a renal biopsy or nephrectomy and CS-exposed mice, we assessed pathologic and ultra-structural renal lesions, and measured urinary albumin: creatinine ratios (UACRs), tissue oxidative stress levels, and AGEs, and RAGE levels in pulmonary and renal endothelial cells. Treating mice having CS-induced pulmonary and renal injury with an angiotensin converting enzyme-inhibitor (Enalapril), limited the progression of both renal and pulmonary disease, and reduced activation of the oxidative stress-AGEs-RAGE pathway in CS-exposed mice.