Associations of persistent organic pollutants (POPs) with diabetes in women from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

摘要: BACKGROUND AND AIM Global diabetes prevalence has risen rapidly in recent decades. Exposure to POPs has been identified as a possible risk factor for diabetes, but the impact on diabetes progression and mechanisms of action are unclear. We explored associations of serum POPs with incident prediabetes and diabetes, and changes in diabetes traits in post-menopausal Hispanic/Latino women. METHOD HCHS/SOL is the largest multiethnic cohort of Hispanics/Latinos in the US. Our sample included 310 normoglycemic and 399 prediabetic women not taking medications related to diabetes or hormones, with an average 6 years of follow-up. The effect of baseline POPs levels on progression from 1) normoglycemia at baseline to prediabetes at follow-up (162/310) and 2) prediabetes at baseline to diabetes at follow-up (195/399) was evaluated using multivariable Poisson regression with robust variance …