Neocortical Limbic Volume Predicts Longitudinal Gait Performance Decline in Older Adults (P4. 026)

摘要: Objective: We assessed longitudinal changes in gait performance and the degree to which baseline neocortical and subcortical limbic MRI volumetric measures predict changes in aging populations. Background: Slowed gait speed and reduced stride length are associated with increased risk for falls in older adults and cognitively impaired populations such as amnestic MCI (aMCI). Design/Methods: Quantitative gait analysis was used to track spatiotemporal gait parameters over a one-year period in 24 community-dwelling older adults without dementia [(ages 77-92, mean = 82.6 (SD 4.6); (10 aMCI, 14 controls; 5 males, 19 females)]. Anatomical T1 MRI was used to measure cortical limbic and basal ganglia brain volumes at baseline. Results: Gait performance declined over the one-year period with a significant slowing of fast gait speed (mean change = 0.12 m/s) and shortened stride length (mean change = - .07 m …