Preclinical MR spectroscopy of GABA: conventional PRESS versus spectral editing with MEGAPRESS and HERMES

摘要: In vivo GABA measurements with conventional (PRESS) and spectral editing methods (MEGAPRESS and HERMES) were investigated in healthy mice at 9.4 T. Animals were divided in two groups, control mice injected with saline and mice injected with Aminooxyacetic acid to intentionally elevate GABA concentration levels (n= 7 per group). Our results show all three methods successfully discriminate GABA from overlapping metabolites with stronger signals. The precision of concentration estimates is more reliable for spectral editing methods given their specificity to GABA. These outcomes suggest spectral editing methods are less susceptible to systematic biases.